Manor house of the Research Center Borstel (FZB) in spring
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BIO
Caroline studied Biology at the University of Bayreuth and received her PhD from the University of Kassel in 2010. During her PhD in the lab of Prof. Markus Maniak she isolated lipid droplets from the model organism Dictyostelium discoideum and characterized the lipid droplet proteome.
In 2011 Caroline started her postdoc in the lab of Prof. Thierry Soldati at the University of Geneva, Switzerland. During the first years, she used the D. discoideum / M. marinum infection system to study lipid droplet dynamics during mycobacteria infection.
2016 she was promoted “maître assistante” and established several tools to monitor lipid flows from D. discoideum to intracellular mycobacteria. Besides lipid metabolism, Caroline also worked on zinc and ZnT transporters and their role in the bactericidal defense of D. discoideum and during mycobacteria infection.
In September 2019 Caroline started the junior research group Molecular Infection Biology at the University of Osnabrück, Germany. The main research interest of the group is to unravel the molecular mechanisms by which intracellular mycobacteria acquire host lipids. In 2023 Caroline Barisch joined the Research Center Borstel (FZB) and the Biology Department of the University of Hamburg. The Barisch lab is now located at Centre for Structural Systems Biology (CSSB) @DESY, Hamburg in autumn 2023.
Caroline studied Biology at the University of Bayreuth and received her PhD from the University of Kassel in 2010. During her PhD in the lab of Prof. Markus Maniak she isolated lipid droplets from the model organism Dictyostelium discoideum and characterized the lipid droplet proteome.
In 2011 Caroline started her postdoc in the lab of Prof. Thierry Soldati at the University of Geneva, Switzerland. During the first years, she used the D. discoideum / M. marinum infection system to study lipid droplet dynamics during mycobacteria infection.
2016 she was promoted “maître assistante” and established several tools to monitor lipid flows from D. discoideum to intracellular mycobacteria. Besides lipid metabolism, Caroline also worked on zinc and ZnT transporters and their role in the bactericidal defense of D. discoideum and during mycobacteria infection.
In September 2019 Caroline started the junior research group Molecular Infection Biology at the University of Osnabrück, Germany. The main research interest of the group is to unravel the molecular mechanisms by which intracellular mycobacteria acquire host lipids. In 2023 Caroline Barisch joined the Research Center Borstel (FZB) and the Biology Department of the University of Hamburg. The Barisch lab is now located at Centre for Structural Systems Biology (CSSB) @DESY, Hamburg in autumn 2023.
Lab Technician
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BIO
Béla is a Biological Technical Assistant who recently graduated from the School of Life Science in Hamburg. His scientific journey took him to Manchester, UK, where he worked in a nutritional laboratory investigating the carotenoid composition of various fruits and human plasma using advanced HPLC methods.
His thirst for knowledge brought him to DESY, where he carried out an internship on the development of specialised smNPC neurons from induced pluripotent stem cells. This work allowed him to explore the complexities of neural development in depth.
At the University of Hamburg, he joined the Behavioral Biology laboratory of Prof. Dr. Jutta Schneider for a second internship. Here, he gained extensive experience working with live subjects, such as Latrodectus spiders and praying mantises thus enhancing his understanding of behavioral science. Since joining Caroline Barisch's lab at CSSB in November 2023, he has been an integral part of pioneering projects in infection biology, contributing his expertise and skills to the forefront of scientific discovery.
Béla is a Biological Technical Assistant who recently graduated from the School of Life Science in Hamburg. His scientific journey took him to Manchester, UK, where he worked in a nutritional laboratory investigating the carotenoid composition of various fruits and human plasma using advanced HPLC methods.
His thirst for knowledge brought him to DESY, where he carried out an internship on the development of specialised smNPC neurons from induced pluripotent stem cells. This work allowed him to explore the complexities of neural development in depth.
At the University of Hamburg, he joined the Behavioral Biology laboratory of Prof. Dr. Jutta Schneider for a second internship. Here, he gained extensive experience working with live subjects, such as Latrodectus spiders and praying mantises thus enhancing his understanding of behavioral science. Since joining Caroline Barisch's lab at CSSB in November 2023, he has been an integral part of pioneering projects in infection biology, contributing his expertise and skills to the forefront of scientific discovery.
Postdoc
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BIO
Aby studied Biotechnology at the Karunya University in India and then came to Germany for higher education. He graduated with a MSc degree in Biosciences at the Julius Maximilians University of Würzburg. For hist master project, he succeeded in achieving the study completion grant from the German Academic Exchange Service (DAAD) and performed his master thesis in Molecular Infection Biology with the group of Roy Gross at the Biocenter, Würzburg. The objective of his master thesis was to investigate the role of dermonecrotic toxin of Bordetella pertussis, the pathogen which causes pertussis, in the interaction with human bronchial epithelial cells. Therefore, he infected monolayers of airway cells and engineered 3D tissue models. He became very interested in understanding the molecular mechanisms underlying host-pathogen interactions. To acquire deeper knowledge in the field of infection biology, he joined the Barisch lab in June 2020 as a PhD student to work on mycobacterial infection using Dictyostelium discoideum as a model host. In September 2023 Aby successfully defended his PhD and moved to the CSSB in October 2023.
Aby studied Biotechnology at the Karunya University in India and then came to Germany for higher education. He graduated with a MSc degree in Biosciences at the Julius Maximilians University of Würzburg. For hist master project, he succeeded in achieving the study completion grant from the German Academic Exchange Service (DAAD) and performed his master thesis in Molecular Infection Biology with the group of Roy Gross at the Biocenter, Würzburg. The objective of his master thesis was to investigate the role of dermonecrotic toxin of Bordetella pertussis, the pathogen which causes pertussis, in the interaction with human bronchial epithelial cells. Therefore, he infected monolayers of airway cells and engineered 3D tissue models. He became very interested in understanding the molecular mechanisms underlying host-pathogen interactions. To acquire deeper knowledge in the field of infection biology, he joined the Barisch lab in June 2020 as a PhD student to work on mycobacterial infection using Dictyostelium discoideum as a model host. In September 2023 Aby successfully defended his PhD and moved to the CSSB in October 2023.
PhD Students
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BIO
Miriam studied Molecular Life Science at the University of Hamburg. During her bachelor studies, she investigated the gene expression of Leishmania donovani parasites, which sparked her passion for infectious diseases and the interaction between host and pathogen. In 2021, she began the Master's programme in Infection Biology at the University of Lübeck. Two internships brought her into contact with the human and murine complement system and Mycobacterium tuberculosis. In her Master's thesis, she used primary human cells (monocyte derived macrophages and neutrophils) infected with Mtb to investigate the oxidative changes in proteins that are part of protective redox systems. In May 2024, she joined the Barisch lab as a PhD student to deepen her knowledge of Mtb and learn how they exploit the host's lipid metabolism to their own advantage.
Miriam studied Molecular Life Science at the University of Hamburg. During her bachelor studies, she investigated the gene expression of Leishmania donovani parasites, which sparked her passion for infectious diseases and the interaction between host and pathogen. In 2021, she began the Master's programme in Infection Biology at the University of Lübeck. Two internships brought her into contact with the human and murine complement system and Mycobacterium tuberculosis. In her Master's thesis, she used primary human cells (monocyte derived macrophages and neutrophils) infected with Mtb to investigate the oxidative changes in proteins that are part of protective redox systems. In May 2024, she joined the Barisch lab as a PhD student to deepen her knowledge of Mtb and learn how they exploit the host's lipid metabolism to their own advantage.
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BIO
Studying at the University of Freiburg, Paulo gained expertise across diverse research domains. As an undergraduate, his research within the Reiff research group focused on animal physiology/neurobiology, investigating the neurological anatomy of Drosophila melanogaster and its motor behavior using genetic and optogenetic methods.
Utilizing pharmacological applications and immunohistological techniques, he later explored neural stem cell niches in Danio rerio embryos in neurodevelopmental biology within the Driever research group.
During his masters, he worked in the neuropathology at the University Clinic Freiburg with the Prinz research group. Here, Paulo enhanced his abilities in immunohistochemical methods, flow cytometry and confocal microscopy. While working on his MSc thesis, he contributed significantly, developing a novel method for culturing tissue-specific macrophages (Aktories et al. 2022). Conducting and analyzing diverse immunoassays like Seahorse and Legendplex, Paulos research focused on “immune metabolic profiling and functional characterisation of tissue-resident macrophage-like cultures”. Alongside his work in academic research, he also enjoyed tutoring BSc students for several years in animal physiology. In 2023, Paulo embarked on a new academic journey, relocating to Hamburg to pursue his PhD in the Barisch Lab. His current research delves into the complexities of mycobacterial infection, utilizing the sophisticated biological mechanisms of human macrophages to gain deeper insights in this important field of research.
Studying at the University of Freiburg, Paulo gained expertise across diverse research domains. As an undergraduate, his research within the Reiff research group focused on animal physiology/neurobiology, investigating the neurological anatomy of Drosophila melanogaster and its motor behavior using genetic and optogenetic methods.
Utilizing pharmacological applications and immunohistological techniques, he later explored neural stem cell niches in Danio rerio embryos in neurodevelopmental biology within the Driever research group.
During his masters, he worked in the neuropathology at the University Clinic Freiburg with the Prinz research group. Here, Paulo enhanced his abilities in immunohistochemical methods, flow cytometry and confocal microscopy. While working on his MSc thesis, he contributed significantly, developing a novel method for culturing tissue-specific macrophages (Aktories et al. 2022). Conducting and analyzing diverse immunoassays like Seahorse and Legendplex, Paulos research focused on “immune metabolic profiling and functional characterisation of tissue-resident macrophage-like cultures”. Alongside his work in academic research, he also enjoyed tutoring BSc students for several years in animal physiology. In 2023, Paulo embarked on a new academic journey, relocating to Hamburg to pursue his PhD in the Barisch Lab. His current research delves into the complexities of mycobacterial infection, utilizing the sophisticated biological mechanisms of human macrophages to gain deeper insights in this important field of research.
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BIO
Anna-Carina completed her BSc degree in Microbiology in the department of Prof. Hensel at the University of Osnabrück where she studied the SiiAB and MotAB protein complexes that play a role for Salmonella adhesion and invasion of polarized epithelial cells.
After the successful completion of her BSc, she chose to continue her academic career in a master's program with a focus on Cell and Molecular Biology. For her MSc thesis she joined the group of Prof. Dr. Caroline Barisch in September 2021. As a PhD student of the SFB1557 ("functional plasticity encoded by cellular membrane networks") she is currently working on the exiting topic of lipid transfer proteins and how they are exploited by mycobacteria during infection. In October 2023 Anna moved to the CSSB in Hamburg together with the other members of the Barisch lab.
Anna-Carina completed her BSc degree in Microbiology in the department of Prof. Hensel at the University of Osnabrück where she studied the SiiAB and MotAB protein complexes that play a role for Salmonella adhesion and invasion of polarized epithelial cells.
After the successful completion of her BSc, she chose to continue her academic career in a master's program with a focus on Cell and Molecular Biology. For her MSc thesis she joined the group of Prof. Dr. Caroline Barisch in September 2021. As a PhD student of the SFB1557 ("functional plasticity encoded by cellular membrane networks") she is currently working on the exiting topic of lipid transfer proteins and how they are exploited by mycobacteria during infection. In October 2023 Anna moved to the CSSB in Hamburg together with the other members of the Barisch lab.
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BIO
Sylvana pursued her MSc at the University of Munich and she performed two research internships in England and Munich to get specialized in Infection Biology. The project at the Bob Champions Research Institute of the University of East Anglia dealt with the influence of enterohaemorrhagic Escherichia coli and their outer membrane vesicles on human macrophages. Furthermore, she investigated the infection processes of human adenovirus at the Department of Molecular Virology of Helmholtz Institute of Neuherberg. From this point on, she wanted to know more about host-pathogen interactions, which is why she started her PhD in April 2021 in the group of Caroline Barisch within the DFG priority program "Exit strategies of intracellular pathogens" (SPP2225). In October 2023 Sylvana moved to the CSSB in Hamburg together with the other members of the Barisch lab.
Sylvana pursued her MSc at the University of Munich and she performed two research internships in England and Munich to get specialized in Infection Biology. The project at the Bob Champions Research Institute of the University of East Anglia dealt with the influence of enterohaemorrhagic Escherichia coli and their outer membrane vesicles on human macrophages. Furthermore, she investigated the infection processes of human adenovirus at the Department of Molecular Virology of Helmholtz Institute of Neuherberg. From this point on, she wanted to know more about host-pathogen interactions, which is why she started her PhD in April 2021 in the group of Caroline Barisch within the DFG priority program "Exit strategies of intracellular pathogens" (SPP2225). In October 2023 Sylvana moved to the CSSB in Hamburg together with the other members of the Barisch lab.
MSc Students
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Hritik Yadav
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BIO
Hritik Yadav is a student pursuing a BS-MS dual degree at the Indian Institute of Science Education and Research (IISER) Mohali, India, where he is majoring in Biology with a minor in Data Science. During this time, he has completed two Internships in IISER Mohali: one in 2022 in a plant developmental lab, where he focused on the auxin protein in the Arabidopsis thaliana plant, and another in 2023 in a biochemistry lab, where he worked on the Vibrio cholerae pore-forming toxins. Hritik growing interest in bacterial research led him to Hamburg in August 2024, where he joined Dr. Caroline Barisch's group at the Center for Structural Systems Biology (CSSB) in Hamburg for his master's thesis. His research there involves protein synthesis and structural analysis, with a focus on an antimicrobial peptide that inhibits Mycobacteria infections.
Hritik Yadav is a student pursuing a BS-MS dual degree at the Indian Institute of Science Education and Research (IISER) Mohali, India, where he is majoring in Biology with a minor in Data Science. During this time, he has completed two Internships in IISER Mohali: one in 2022 in a plant developmental lab, where he focused on the auxin protein in the Arabidopsis thaliana plant, and another in 2023 in a biochemistry lab, where he worked on the Vibrio cholerae pore-forming toxins. Hritik growing interest in bacterial research led him to Hamburg in August 2024, where he joined Dr. Caroline Barisch's group at the Center for Structural Systems Biology (CSSB) in Hamburg for his master's thesis. His research there involves protein synthesis and structural analysis, with a focus on an antimicrobial peptide that inhibits Mycobacteria infections.
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BSc Danica Müller
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BIO
Danica completed her BSc in the division of Zoology at the University of Osnabrück with Prof. Purschke. Her thesis was focused on the bioluminescence in marine annelids. She decided to continue her studies in the master's programme at the University of Osnabrück after successfully completing her BSc and joined the division of Molecular Infection Biology in November 2022. The development of a novel macrophage/M. marinum model system is the focus of her master's thesis.
Danica completed her BSc in the division of Zoology at the University of Osnabrück with Prof. Purschke. Her thesis was focused on the bioluminescence in marine annelids. She decided to continue her studies in the master's programme at the University of Osnabrück after successfully completing her BSc and joined the division of Molecular Infection Biology in November 2022. The development of a novel macrophage/M. marinum model system is the focus of her master's thesis.
BSc Students
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